Serine/threonine-protein kinase pim-2, also known as PIM2, is a serine/threonine protein kinase in the CAMK family. PIM2 is expressed in many tissues, with high levels in spleen, thymus, testis, small intestine, and colon. It is implicated in tumor phenotypes and may be involved in the formation and preservation of Long-Term Potentiation (LTP), a profuse, activity-dependent enhancement of synaptic efficacy that is implicated in long-term memory. Recombinant human PIM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.