NF-kappa-B inhibitor alpha, also known as NFKBIA, is members of the IκB family of proteins can be divided into four groups (IκB-α, IκB-β, IκB-γ, IκB-ε). NFKBIA inhibits the NFκB complex by binding and sequestering it in the cytoplasm. Upon stimulation, NFKBIA is phosphorylated on serine residues marking it for degradation by the ubiquitin pathway.