Protein AF1q, also known as MLLT11, belongs to the Mixed-Lineage Leukemia (MLL) protein family. It is located on chromosome 11q23. MLLT11 plays a role in leukemogenesis and, specifically, the progression of acute monocytic leukemia (AML). Also, expressed in embryonic brain cortex, MLLT11 is upregulated during neuronal differentiation and is thought to play a role in the development of the central nervous system. Recombinant human MLLT11 protein, fused to His-tag at N-terminus, was expressed in E.coli.