Lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1), a selective marker of the lymphatic endothelium, is a surface endocytic receptor for hyaluronan (HA), which is an extracellular glycosaminoglycan involved in cell adhesion and migration. LYVE1 is also known as XLKD1 and may function in lympathic hyaluronan transport and have a role in tumor metastasis.