The human LY6G6F protein is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, which is comprised of cell-surface proteins involved in the immune system and cellular recognition. This protein may play a role in the downstream signal transduction pathways involving GRB2 and GRB7. Recombinant human LY6G6F protein, fused to His-tag at N-terminus, was expressed in E.coli .