U6 snRNA-associated Sm-like protein LSm1, also known as LSM1 plays a role in replicationdependent histone mRNA degradation and binds specifically to the 3'-terminal U-tract of U6 snRNA. LSM1 protein facilitates RNA protein interactions and structural changes that are required during ribosomal subunit assembly. LSM1 is naturally overexpressed in pancreatic cancer as well as in certain breast cancer cell lines.