LRRC59 is required for nuclear import of FGF1, but not that of FGF2. This proein might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores. Recombinant human LRRC59 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.