FLRT2, also known as leucine-rich repeat transmembrane protein FLRT2, is one of three FLRT (fibronectin, leucine rich repeat, transmembrane) glycoproteins expressed in distinct areas of the developing brain and other tissues. Human FLRT1 and FLRT3 ECDs (extracellular domain) share approximately 47% aa identity with FLRT2. The fibronectin domain of all three FLRTs can bind to FGF receptors. Recombinant human FLRT2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.