IMMP2L is a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. This protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. Recombinant human IMMP2L protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.