IL17RB, also known as Interleukin-17 receptor B, is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. It has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. It was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. Recombinant human IL17RB, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.