HHEX is a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. HHEX has been shown to interact with Promyelocytic leukemia protein. Recombinant human HHEX protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.