GNG12 also known as Guanine nucleotide-binding protein G(I)/G(S)/G(O)subunit gamma-12. This protein is Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Recombinant human GNG12 protein, was expressed in E.coli