GNG11 is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. Recombinant human GNG11 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.