GCET2 is a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosinebased activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Recombinant human GCET2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.