Fcgrt, as known as IgG receptor FcRn large subunit p51, is a transmembrane glycoprotein with structural homology to MHC class 1 proteins. This protein is widely expressed in endothelial and epithelial cells and plays an important rloe in IgG homeostasis. Also, it is expessed in neutrophils and myeloid antigen presenting cells. It can enhance IgG-meditated phagocytosis and antigen presentation by heses cells, but it promotes the degradation of opsonizing IgG rather than returning it to the circulation. Recombinant mouse Fcgrt, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.