FCGR1A, also known as CD64, belongs to the immunoglobulin superfamily. This protein is high affinity receptor for the Fc region of immunoglobulins gamma. It plays an important role in both innate and adaptive immune response. Recombinant human FCGR1A protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.