EPHA2, also known as ephrin type-A receptor 2, is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. It is implicated as positional labels that may guide the development of neural topographic maps. It has also been found implicated in embryonic patterning, neuronal targeting, vascular development and adult neovascularization. Recombinant human EPHA2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques