c-MPL/TPOR (AMM2) Anti-Mouse Rat IgG MoAb

抗血小板生成素受体单克隆抗体

Thrombopoietin promotes the growth and differentiation (proliferation) of megakaryocytes which produce platelets. TPOR (Thrombopoietin receptor), which is also called c-MPL (Myeloproliferative leukemia protein) or CD110, is a receptor for thrombopoietin. And it is suggested that TPOR may also play a role in the maintenance of hematopoietic stem cells, which are stem cells located within the bone marrow that have the potential to develop into red blood cells, white blood cells, megakaryocytes and platelets. This receptor is activated when thrombopoietin protein binds to it, and the activated receptor stimulates a signaling pathway called the JAK/STAT pathway, which transmits signals from outside the cell to the cell's nucleus and is important for controlling the production of blood cells. This antibody specifically reacts with mouse c-MPL/TPOR protein, and has neutralization activity to the reaction with thrombopoietin ligand (ref. 5).
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基本信息

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货号 MA01128
规格 100 μg
宿主 Rat
免疫原 Recombinant protein of mouse c-MPL extracellular domain
特异性
亚型 IgG1
反应性 Mouse
克隆 AMM2
Uniprot
浓度 Please see datasheet.
推荐稀释度
配方 Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3
应用范围 WB, immuno-precipitation, flow cytometry.
别名
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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