Anti-Human ZEB1 Monoclonal Antibody

ZEB1单克隆抗体

ZEB1(zinc-finger-enhancer binding protein 1),which is a members of the Zincfinger-Homeobox (ZFH)-family of repressors,acts as a transcriptional repressor that inhibits interleukin-2 (IL-2) gene expression. Depending on the quantity of cDNA and on the cell type,ZEB1 can enhance or repress the promoter activity of the ATP1A1 gene . Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. The calculated molecular weight of ZEB1 is 124 kDa,but the post phosphorylation of protein is about 190-210 kDa.
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基本信息

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货号 MA02184
规格 100μl
宿主 Mouse
免疫原 Fusion protein of ZEB1
特异性 Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.
亚型 IgG1
反应性 Human
克隆 156
Uniprot P37275
浓度 None
推荐稀释度 WB 1:500-1:5000
配方
应用范围 WB,ELISA
别名 AREB 6,BZP,Delta crystallin enhancer binding factor 1,DELTA EF1,FECD6,MGC133261,Negative regulator of IL 2,Negative regulator of IL2,NIL 2 A,NIL 2 A zinc finger protein,NIL 2A,NIL-2-A zinc finger protein,NIL2A,Posterior polymorphous corneal dystrophy 3,PPCD3,Represses interleukin 2 expression,TCF 8,TCF-8,TCF8,Transcription factor 8 (represses interleukin 2 expression),Transcription factor 8,ZEB 1,ZEB,ZEB1,ZEB1,ZFHEP,ZFHX 1A,ZFHX1A,Zinc finger E box binding homeobox 1,Zinc finger E-box-binding homeobox 1,Zinc finger homeodomain enhancer binding protein
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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