VPS37A,also named as HCRP1,belongs to the VPS37 family. It is a regulator of vesicular trafficking process. VPS37A is a member of the endosomal sorting complex required for transport (ESCRT) system,in upper motor neuron disease. ESCRT has been shown to play a central role in intracellular trafficking,in the maturation of multivesicular bodies and the sorting of ubiquitinated membrane proteins into internal luminal vesicles.