VIPR1 encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene.VIPR1 (Vasoactive Intestinal Peptide Receptor 1) is a Protein Coding gene. Diseases associated with VIPR1 include Holoprosencephaly-3 and Inflammatory Diarrhea. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and vasoactive intestinal polypeptide receptor activity. An important paralog of this gene is ADCYAP1R1.