UBE2C(Ubiquitin-conjugating enzyme E2 C) is also known as UBCH10 and belongs to the ubiquitin-conjugating enzyme family. It is highly expressed in a variety of human primary tumors,and it is able to promote cell proliferation and malignant transformation. UBE2C,along with the E3 ligase of the anaphasepromoting complex (APC),catalyzes the ubiquitination of mitotic cyclins A and B,as well as securin. UBE2C is essential for cell cycle progression,and mutation of its active site cysteine confers a dominant-negative phenotype.