TRIM44 is one of the family member of TRIM protein,which contains an N-terminal ubiquitin hydrolase-type zinc-finger domain,followed by a coiled-coil domain,a zinc-finger B-box homology domain,and a second coiled-coil domain near the C-terminus. Members of the TRIM protein family are involved in various cellular processes,such as cell proliferation,oncogenesis and antiviral defense.