TELO2 gene encodes a telomere length regulation protein TEL2 homolog. TELO2 may be involved in telomere length regulation and can form TTT complex with TTI1 and TTI2. TTT complex is required to stabilize protein levels of PIKK family proteins and is involved in the cellular resistance to DNA damage stresses,like ionizing radiation (IR),ultraviolet (UV) and mitomycin C (MMC). The activity of mTORC1 and mTORC2 complexes,which regulate cell growth and survival in response to nutrient and hormonal signals,can be promoted,stabilized and maintained by TELO2.