Via antagonizing chromatin-mediated transcriptional repression,the SWI/SNF complex in S. cerevisiae and Drosophila is thought to facilitate transcriptional activation of specific genes. The BRG1/brm-associated factors,or SMARCE1,complex in mammals is functionally related to SWI/SNF and consists of 9 to 12 subunits,some of which are homologous to SWI/SNF subunits. It contains a DNA-binding HMG domain and performs multiple biological functions,including DNA-,protein- and chromatin-binding,transcription coactivating activity,chromatin modification,DNA-dependent negative regulation of transcription,regulation of transcription of the RNA polymerase II promoter. In addition,SMARCE1,as an ER (estrogen receptor) subtype-selective modulator,regulates ER mediated transcription in a ligand-dependent manner and also directly binds to AR (androgen receptor) to alter its activity