SMARCD1 (SWI/SNF related,matrix associated,actin dependent regulator of chromatin,subfamily d,member 1),also known as BAF60a (BRG1-associated factor 60A),Rsc6p or CRACD1,is a 476 amino acid protein that localizes to the nucleus and contains one SWIB domain. Expressed ubiquitously with notable expression in liver,brain,muscle, lung,kidney,pancreas and placenta,SMARCD1 functions as a component of the BAF complex and,in conjunction with a variety of other proteins,plays an essential role in chromatin remodeling. In addition,SMARCD1 influences vitamin D-mediated transcriptional activity and is thought to provide a link between the vitamin D receptor (VDR) and SWI/SNF chromatin remodeling complexes. Multiple isoforms of BAF60a exist due to alternative splicing events.