SERPINE2 also called protease nexin-1 or glial-derived neurite promoting factor,is a member of the serine protease inhibitor (SERPIN) superfamily. It would be a potent inhibitor of the urokinase-plasminogen activator (uPA),tissue-type PA (tPA),thrombin,trypsin,factor Xia,and prostasin. SERPINE2 is widely expressed in various tissues,including endothelial cells,fibroblasts,smooth muscle cells,tumor cells,glial cells,neurons,and placental cells.