RXRG,also named as,Retinoic acid receptor RXR-gamma,is a 463 amino acid protein,which localize in the nucleus and may form homodimer. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands,all-trans or 9-cis retinoic acid,and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5.