Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants.RIN3 (Ras And Rab Interactor 3) is a Protein Coding gene. Diseases associated with RIN3 include Paget's Disease Of Bone. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. GO annotations related to this gene include GTPase activator activity and Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIN2.