Secreted frizzled-related protein 2 (Sfrp2) is a secreted glycoprotein molecule containing an N terminal cysteine-rich domain,which is typically 30-50% identical to the putative Wnt-binding site of the frizzled receptor,and a C terminal heparin-binding domain with weak homology to netrins. It has been implicated in diverse cellular processes,including embryogenesis,regulation of cell apoptosis,and cell differentiation. Methylation of this gene is a potential marker for the presence of colorectal cancer.