Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential,transepithelial transport,maintenance of intracellular pH,and regulation of cell volume. CLIC4 is a p53- and tumor necrosis factor alpha-regulated cytoplasmic and mitochondrial protein that belongs to the CLIC family of intracellular chloride channels. CLICs have actions distinct from traditional cell membrane chloride channels,including formation of ion channels in intracellular organelles and roles in membrane trafficking,apoptosis,and cell differentiation.