The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene.ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit) is a Protein Coding gene. Diseases associated with ATP12A include Bladder Calculus and Gastroduodenal Crohn's Disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include nucleotide binding and hydrogen:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1A1.