This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants.PTGR2 (Prostaglandin Reductase 2) is a Protein Coding gene. Among its related pathways are Arachidonic acid metabolism and Metabolism. GO annotations related to this gene include oxidoreductase activity and 15-oxoprostaglandin 13-oxidase activity. An important paralog of this gene is ENSG00000258653.