This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.PRSS3 (Protease, Serine 3) is a Protein Coding gene. Diseases associated with PRSS3 include Thyroiditis and Pancreatitis. Among its related pathways are Collagen chain trimerization and Defensins. GO annotations related to this gene include calcium ion binding and serine-type peptidase activity. An important paralog of this gene is PRSS2.