PDCD10,also named CCM3 and TFAR15,belongs to the PDCD10 family. PDCD10 promotes cell proliferation,increases MAPK activity and modulates apoptotic pathways. PDCD10 is important for cell migration and for normal structure and assembly of the Golgi complex. PDCD10 is required for normal angiogenesis,vasculogenesis and hematopoiesis during embryonic development,moreover,defects in PDCD10 showed abnormal cardiovascular development.