Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. P-cadherin (placental cadherin),also known as CDH3 (cadherin 3),is a classical member of the cadherin superfamily which also include E-,N-,R-,and B-cadherins. Aberrant expression of P-cadherin has been reported in many cancers,including breast,gastric,endometrial,ovarian,and prostate cancer.