The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene.OIP5 (Opa Interacting Protein 5) is a Protein Coding gene. Among its related pathways are Chromosome Maintenance and Cell Cycle, Mitotic.