Numbl (also known as numblike or Nbl),as a conserved homolog of Drosophila Numb,is specfically expressed in the brain. Numbl is a cytoplasm protein and has redundant functions in embryonic neurogenesis. It plays an important role in ependymal wall integrity and subventricular zone neuroblast survival. However,its expression and function in the central nervous system lesion are still unclear.