SRPX2 (sushi-repeat-containing protein,X-linked 2) is a secreted protein expressed in neurons of the human adult brain,including the rolandic area . Firstly described as sushi-repeat protein up-regulated in leukemia (SPRUL) in leukemia cells with dysregulated expression at the transcriptional level,SRPX2 has been recently shown as a multifunctional protein. SRPX2 is a ligand for uPAR,the urokinase-type plasminogen activator (uPA) receptor . It is involved in seizure disorders,angiogenesis and cellular adhesion . The involvement of SRPX2 in disorders of language cortex and cognition suggests it has an important role in the perisylvian region critical for language and cognitive development .