The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene.SEC23B (Sec23 Homolog B, Coat Complex II Component) is a Protein Coding gene. Diseases associated with SEC23B include Dyserythropoietic Anemia, Congenital, Type Ii and Cowden Syndrome 7. Among its related pathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and Chks in Checkpoint Regulation. An important paralog of this gene is SEC23A.