S100A11,also named as MLN 70,Calgizzarin and S100C,Belongs to the S-100 family. It facilitates the differentiation and the cornification of keratinocytes. The naming of S100A11 systematically arises from its membership of the S100 protein family,named after their solubility in 100% saturated ammonium sulfate solution. First discovered in 1989,S100A11 has since been proposed to have direct biological functions in an assortment of physiological processes such as endo- and exocytosis,regulation of enzyme activity,cell growth and regulation,apoptosis and inflammation.