Anti-Human/Mouse/Rat STAT5B Polyclonal Antibody

STAT5B多克隆抗体

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
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基本信息

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货号 PA04245
规格 100μl
宿主 Rabbit
免疫原 Recombinant Protein
特异性
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot P51692
浓度 1mg/mL
推荐稀释度 WB 1:500-1:2000, IHC 1:50-1:200
配方
应用范围 WB,IHC-p
别名 Signal transducer and activator of transcription 5B,STA5B,STAT5,Stat5b,Transcription factor STAT5B
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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