SOD2(superoxide dismutase 2,mitochondrial ) is also named as IPOB,MNSOD,SODM,Mn-SOD and belongs to the iron/manganese superoxide dismutase family. It is a marker of mitochondria,which is restricted to the perinuclear area in a cell with aggregate formation of mutant SOD1. It functions as the first line of antioxidant defense against highly reactive superoxide radicals and it appears to be early predictors for survival in septic patients with with MIF. It has 2 isoforms with the molecular weight of 25 kDa and 21 kDa.