This gene likely encodes a member of the arginine/serine-rich splicing factor family. A similar protein in Rat appears to bind the large subunit of RNA polymerase II and provide a link between transcription and pre-mRNA splicing. Alternatively spliced transcript variants have been described.SCAF4 (SR-Related CTD Associated Factor 4) is a Protein Coding gene. Diseases associated with SCAF4 include Hay-Wells Syndrome and Wells Syndrome. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SCAF8.