Anti-Human/Mouse/Rat RHOA Polyclonal Antibody

RHOA多克隆抗体

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
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基本信息

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货号 PA05745
规格 100μl
宿主 Rabbit
免疫原 Synthesized peptide derived from human Rho A around the non-phosphorylation site of Ser188.
特异性
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot P61586
浓度 1mg/mL
推荐稀释度 WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:5000
配方
应用范围 WB,IHC-p,IF,ELISA
别名 Aplysia ras related homolog 12,ARH12,ARHA,H 12,H12,Oncogene RHO H12,Ras homolog family member A,Ras homolog gene family member A,Rho A,Rho cDNA clone 12,RHO H12,RHO12,RHOA,RHOA,RHOH12,Small GTP binding protein Rho A,Transforming protein Rho A,Transforming protein RhoA
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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