Anti-Human/Mouse/Rat RAN Polyclonal Antibody

RAN多克隆抗体

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
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基本信息

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货号 PA10786
规格 100μl
宿主 Rabbit
免疫原 Synthetic peptide of human RAN
特异性 Expressed in a variety of tissues.
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot P62826
浓度 0.2 mg/mL
推荐稀释度 WB 1:200-1:1000, IHC 1:25-1:100
配方
应用范围 WB,IHC,ELISA
别名 Androgen receptor associated protein 24,Androgen receptor-associated protein 24,ARA 24,ARA24,Gsp1,GTP binding nuclear protein RAN,GTP-binding nuclear protein Ran,GTPase Ran,Guanosine triphosphatase Ran,LPS,OK/SW-cl.81,ran,RAN member RAS oncogene family,RAN,RanGTPase,Ras like protein TC4,Ras related nuclear protein,Ras-like protein TC4,Ras-related nuclear protein,RASL2 8,TC 4,TC4
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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