Phospholipase A-2-activating protein (PLAA),also named PLAP,can interact with ubiquitin and is involved in the maintenance of ubiquitin levels. PLAA contains multiple consensus domains including WD repeats,PFU domain and PUL domain. Although the function of PLAA remains unclear,ubiquitin binding of PLAA might be the central role that connects ubiquitination and degradation in ERAD. Recent finding revealed that PLAA served as a novel nociveptive mediator after incision,and its expression level is regulated by miR-203.