Anti-Human/Mouse/Rat Phospho-SMC1A (Ser966) Polyclonal Antibody

Phospho-SMC1A (Ser966)多克隆抗体

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
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基本信息

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货号 PA04092
规格 100μl
宿主 Rabbit
免疫原 Synthesized peptide derived from human SMC1 around the phosphorylation site of S966.
特异性
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot Q14683
浓度 1mg/mL
推荐稀释度 WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
配方
应用范围 WB,IHC-p,ELISA
别名 Chromosome segregation protein SmcB,DXS423E,KIAA0178,MGC138332,Sb1.8,Segregation of mitotic chromosomes 1,SMC protein 1A,SMC-1-alpha,SMC-1A,SMC1 (structural maintenance of chromosomes 1 yeast) like 1,SMC1,SMC1 structural maintenance of chromosomes 1 like 1,SMC1A,SMC1A,SMC1alpha,SMC1L1,SMCB,Structural maintenance of chromosomes 1A,Structural maintenance of chromosomes protein 1A
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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