Anti-Human/Mouse/Rat Phospho-PGR (Ser294) Polyclonal Antibody

Phospho-PGR (Ser294)多克隆抗体

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation.Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
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基本信息

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货号 PA01733
规格 100μl
宿主 Rabbit
免疫原 Synthesized peptide derived from human PR around the phosphorylation site of S294.
特异性 In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region-specific responses to hormonal stimuli.
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot P06401
浓度 1mg/mL
推荐稀释度 WB 1:500-1:2000, IF 1:200-1:1000, ELISA 1:5000
配方
应用范围 WB,IF,ELISA
别名 NR3C3,Nuclear receptor subfamily 3 group C member 3,PGR,PR,PRA,PRB,PRGR,Progesterone receptor,Progestin receptor form A,Progestin receptor form B
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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