Anti-Human/Mouse/Rat Phospho-Pan-Akt (Ser473) Polyclonal Antibody

Phospho-Pan-Akt (Ser473)多克隆抗体

Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.
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基本信息

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货号 PA01497
规格 100μl
宿主 Rabbit
免疫原 Synthesized peptide derived from human Akt around the phosphorylation site of Ser473
特异性
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot
浓度 1mg/mL
推荐稀释度 WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:40000
配方
应用范围 WB,IHC-p,IF,ELISA
别名 AKT1,PKB,RAC,RAC-alpha serine/threonine-protein kinase,Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha,AKT2,RAC-beta serine/threonine-protein kinase,Protein kinase Akt-2,Protein kinase B
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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